This supports the idea that predictive biomarkers for adaptive radiotherapy may not require new scans or technology, only better use of the data we already collect
Zhuolin Yang
University of Edinburgh scientists examined daily imaging data from 187 patients treated with prostate radiotherapy, using machine learning tools to identify links between radiomic features and the development of rectal bleeding within two years after therapy. Patterns observed from single scans one week into treatment were highly predictive of later rectal bleeding. Combining data from the first three weeks of scans was found to give the most reliable prediction. The findings suggest tracking radiomic features could provide a valuable early window for intervention that could improve or personalise radiotherapy, experts say.
“The key result here is that early treatment imaging contains quantitative information about later toxicity risk, long before symptoms occur,” explained Dr Zhuolin Yang, Research Fellow at the University’s Institute of Genetics and Cancer. “This supports the idea that predictive biomarkers for adaptive radiotherapy may not require new scans or technology, only better use of the data we already collect.” The approach could one day be integrated into routine treatment planning and monitoring to help clinicians decide when and how to adjust prostate radiotherapy plans, researchers suggest. But they caution this is likely to take many years and the findings should be confirmed with a larger study.
The study was funded by Prostate Cancer UK. The research team included scientists from the University of Cambridge and The Christie NHS Foundation Trust. “This study gives a proof-of-concept that imaging collected for beam setup could support future adaptive workflows. Future trials and automation will be essential before approaches like this can be integrated into clinical decision-making,” said Professor Bill Nailon, Clinical Scientist at the Edinburgh Cancer Centre.
“Radiotherapy is a very common treatment used to cure prostate cancer,” said Dr Hayley Luxton, Head of Research Impact at Prostate Cancer UK. “While very effective, the natural movement of the prostate and surrounding organs during treatment can lead to damage to the surrounding areas, causing bleeding and other side effects that can have a significant impact on men’s lives. We know there’s a need to make treatments kinder, so that’s why in partnership with Movember and the Garfield Weston Foundation we funded this research to identify which men are most likely to have these side effects and change their treatment plan early, avoiding these issues without compromising the effect on the cancer itself. While more research is needed in larger groups of men, this marks a great step forward in personalising radiotherapy to make it kinder and better for more men who need it.”
Source: University of Edinburgh